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| Week | Date | Visitor | Score | @ | Home | Score |
| 01 | 11-Sep | Lions | 27 | @ | Buccaneers | 20 |
| 02 | 18-Sep | Chiefs | 3 | @ | Lions | 48 |
| 03 | 25-Sep | Lions | 26 | @ | Vikings | 23 |
| 04 | 02-Oct | Lions | 34 | @ | Cowboys | 30 |
| 05 | 10-Oct | Bears | 13 | @ | Lions | 24 |
| 06 | 16-Oct | 49ers | 25 | @ | Lions | 19 |
| 07 | 23-Oct | Falcons | 23 | @ | Lions | 16 |
| 08 | 30-Oct | Lions | 45 | @ | Broncos | 10 |
| 09 | Bye | |||||
| 10 | 13-Nov | Lions | 13 | @ | Bears | 37 |
| 11 | 20-Nov | Panthers | 35 | @ | Lions | 49 |
| 12 | 24-Nov | Packers | 27 | @ | Lions | 15 |
| 13 | 04-Dec | Lions | 17 | @ | Saints | 31 |
| 14 | 11-Dec | Vikings | 28 | @ | Lions | 34 |
| 15 | 18-Dec | Lions | 28 | @ | Raiders | 27 |
| 16 | 24-Dec | Chargers | 10 | @ | Lions | 38 |
| 17 | 01-Jan | Lions | 41 | @ | Packers | 45 |
NFC NORTH
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